Getting My ceesdekker.net To Work
Getting My ceesdekker.net To Work
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our study pursuits incorporate:
1996, first mesoscopic cost density waves equipment; and 1st electrical measurements on a single metal nanocluster involving nanoelectrodes
Throughout the exact same time, the team of Paul McEuen, who was then centered with the University of California, Berkeley, confirmed equivalent results on ropes of bundled nanotubes. Depending on the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed applying scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of unique DNA molecules recaptured nearly a thousand situations in a very stable point out nanopore
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Our research ranges from the biophysics of DNA to artificial cells and past. Make sure you have a look below at the spectrum of our current jobs.
Many associated developments followed, exactly where our group set up distinct transistor variants for instance one-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled various transistors into modest evidence-of-theory electronic circuits.
Illustration (one) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, in addition to a 3D rendering in the movement of your DNA rod is shown.
The rotors harness Power from the nanoscale drinking water and ion flow that is produced by a static chemical or electrochemical opportunity gradient while in the nanopore, which can be set up via a salt gradient or utilized voltage, respectively. These synthetic nanoengines self-Arrange and work autonomously in physiological ailments, suggesting approaches to developing Strength-transducing motors at nanoscale interfaces.
There was just one challenge nevertheless — we didn't notice any measurable electrical conduction from ceesdekker the single polymer molecules. We concluded that at the single-molecule level, conducting polymers were really not this sort of wonderful conductors, which was relatively disappointing. We As a result broadened our watch to test to seek out far more promising molecules.
Illustration (4) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in gray, the rim in the pore is highlighted in red, in addition to a 3D rendering with the motion from the DNA rod is exhibited.
Cees Dekker is Distinguished University Professor at TU Delft. Trained as a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes in the 1990s. Since 2000, he moved to one-molecule biophysics and nanobiology. His present-day investigate concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, particularly SMC motor protein; and (iii) building a living artificial mobile from lifeless molecules. Dekker is surely an elected member in the KNAW and fellow for the APS as well as the IOP.
2008, to start with observation of protein-coated DNA translocation as a result of nanopores; fixed the origin with the electrophoretic pressure on DNA in nanopores; uncovered a major velocity boost of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent style and design in 2005. (nl)